InnateDB Protein
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IDBP-17692.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RICTOR
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Protein Name
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RPTOR independent companion of MTOR, complex 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000296782
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InnateDB Gene
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IDBG-17688 (RICTOR)
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Protein Structure
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Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269PubMed:15268862, ECO:0000269PubMed:15467718, ECO:0000269PubMed:15718470}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
112
[view]
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Protein-Protein |
110
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
GO:0001938
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positive regulation of endothelial cell proliferation
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GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0009790
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embryo development
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GO:0030838
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positive regulation of actin filament polymerization
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GO:0031295
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T cell costimulation
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GO:0031532
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actin cytoskeleton reorganization
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GO:0031929
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TOR signaling
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GO:0032008
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positive regulation of TOR signaling
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GO:0032314
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regulation of Rac GTPase activity
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GO:0032956
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regulation of actin cytoskeleton organization
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0042325
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regulation of phosphorylation
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GO:0045087
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innate immune response (InnateDB)
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0051896
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regulation of protein kinase B signaling
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GO:0051897
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positive regulation of protein kinase B signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6R327
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PhosphoSite |
PhosphoSite-Q6R327
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
253260
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UniGene |
Hs.670518
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RefSeq |
NP_001272368
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HUGO |
HGNC:28611
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OMIM |
609022
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CCDS |
CCDS68861
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HPRD |
10682
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IMGT |
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EMBL |
AB082530
AC008964
AC109467
AL834497
AY515854
BC051729
BC137163
BC137164
BC144509
CH471119
CR749280
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GenPept |
AAH51729
AAI37164
AAI37165
AAI44510
AAS79796
BAC02708
CAD39155
CAH18135
EAW55980
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