InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad54l

Summary

InnateDB Protein

IDBP-177439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad54l

Protein Name

RAD54 like (S. cerevisiae)

Synonyms

RAD54;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099766

InnateDB Gene

IDBG-177437 (Rad54l)

Protein Structure

UniProt Annotation

Function

Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). Deficient mice also show significantly shorter telomeres than wild-type controls, indicating that the protein activity plays an essential role in telomere length maintenance in mammals. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non- homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations. {ECO:0000250, ECO:0000269PubMed:10209103, ECO:0000269PubMed:10757799, ECO:0000269PubMed:12218123, ECO:0000269PubMed:12531026, ECO:0000269PubMed:12548566, ECO:0000269PubMed:12897131, ECO:0000269PubMed:15175260, ECO:0000269PubMed:9108475}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Hardly detectable in most tissues. Dramatically increased in thymus, spleen and testis. {ECO:0000269PubMed:8805304}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0036310	annealing helicase activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000733	DNA strand renaturation
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0042493	response to drug
GO:0051276	chromosome organization

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:894697

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR013967 Rad54, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021006 Histone deacetylase complex, subunit 2/3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF04851
PF00270
PF08658
PF11496

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70270