Mus musculus Protein: Rad54l | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-177441.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Rad54l | ||||||||||||||||||
Protein Name | RAD54 like (S. cerevisiae) | ||||||||||||||||||
Synonyms | RAD54; | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000099765 | ||||||||||||||||||
InnateDB Gene | IDBG-177437 (Rad54l) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). Deficient mice also show significantly shorter telomeres than wild-type controls, indicating that the protein activity plays an essential role in telomere length maintenance in mammals. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non- homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations. {ECO:0000250, ECO:0000269PubMed:10209103, ECO:0000269PubMed:10757799, ECO:0000269PubMed:12218123, ECO:0000269PubMed:12531026, ECO:0000269PubMed:12548566, ECO:0000269PubMed:12897131, ECO:0000269PubMed:15175260, ECO:0000269PubMed:9108475}. | ||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000305}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Hardly detectable in most tissues. Dramatically increased in thymus, spleen and testis. {ECO:0000269PubMed:8805304}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:894697 | ||||||||||||||||||
InterPro |
IPR000330
SNF2-related IPR001650 Helicase, C-terminal IPR006935 Helicase/UvrB domain IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal IPR013967 Rad54, N-terminal IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR021006 Histone deacetylase complex, subunit 2/3 IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00176
PF00271 PF04851 PF00270 PF08658 PF11496 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00490
SM00487 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P70270 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P70270 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 19366 | ||||||||||||||||||
UniGene | Mm.3655 | ||||||||||||||||||
RefSeq | NP_033041 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Rad54l | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS18504 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK088876 BC021643 X97796 | ||||||||||||||||||
GenPept | AAH21643 BAC40627 CAA66380 | ||||||||||||||||||