Version 5.4
Mus musculus Protein: Grsf1
Summary
InnateDB Protein IDBP-177459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grsf1
Protein Name G-rich RNA sequence binding factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000077972
InnateDB Gene IDBG-177457 (Grsf1)
Protein Structure
UniProt Annotation
Function Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Note=Forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008033 tRNA processing
GO:0009952 anterior/posterior pattern specification
GO:0016331 morphogenesis of embryonic epithelium
Cellular Component
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID MGI:106479
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C5Q4
PhosphoSite PhosphoSite-Q8C5Q4
TrEMBL Q8C298
UniProt Splice Variant
Entrez Gene 231413
UniGene Mm.472981
RefSeq NP_848815
MGI ID
MGI Symbol Grsf1
OMIM
CCDS CCDS19404
HPRD
IMGT
EMBL AC121541 AC160533 AK044889 AK045986 AK077782 AK089014
GenPept BAC32129 BAC32561 BAC37006 BAC40702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca