InnateDB Protein
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IDBP-1787.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SS18
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Protein Name
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synovial sarcoma translocation, chromosome 18
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Synonyms
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SSXT; SYT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000269137
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InnateDB Gene
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IDBG-1783 (SS18)
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Protein Structure
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Function |
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. {ECO:0000269PubMed:15919756}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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Tissue Specificity |
Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
40
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR007726
SS18 family
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PFAM |
PF05030
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15532
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PhosphoSite |
PhosphoSite-Q15532
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TrEMBL |
Q6FGL9
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UniProt Splice Variant |
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Entrez Gene |
6760
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UniGene |
Hs.707065
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RefSeq |
NP_005628
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HUGO |
HGNC:11340
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OMIM |
600192
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CCDS |
CCDS54183
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HPRD |
02559
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IMGT |
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EMBL |
AC091021
AF343880
AK301504
AK304305
AK316302
BC096221
BC096223
BC096224
CH471088
CR542088
CR542103
EF445031
S79894
X79200
X79201
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GenPept |
AAB35674
AAH96221
AAH96223
AAH96224
AAK21314
ACA06073
BAG63015
BAG65158
BAH14673
CAA55792
CAG46885
CAG46900
EAX01209
EAX01210
EAX01213
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