Version 5.4
Homo sapiens Protein: DIS3L
Summary
InnateDB Protein IDBP-17935.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIS3L
Protein Name DIS3 mitotic control homolog (S. cerevisiae)-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000321711
InnateDB Gene IDBG-17931 (DIS3L)
Protein Structure
UniProt Annotation
Function Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269PubMed:20531386, ECO:0000269PubMed:20531389}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:20531386, ECO:0000269PubMed:20531389}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0016075 rRNA catabolic process
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0000177 cytoplasmic exosome (RNase complex)
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TF46
PhosphoSite PhosphoSite-Q8TF46
TrEMBL E9PS35
UniProt Splice Variant
Entrez Gene 115752
UniGene Hs.446251
RefSeq NP_001137160
HUGO HGNC:28698
OMIM 614183
CCDS CCDS45286
HPRD 11355
IMGT
EMBL AB075835 AC055855 AK095407 BC014124 BC022089 CH471082
GenPept AAH14124 AAH22089 BAB85541 BAC04542 EAW77759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca