Version 5.4
Mus musculus Protein: Cops8
Summary
InnateDB Protein IDBP-179991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops8
Protein Name COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
Synonyms 9430009J09Rik; AA408242; Csn8; Sgn8;
Species Mus musculus
Ensembl Protein ENSMUSP00000035884
InnateDB Gene IDBG-179989 (Cops8)
Protein Structure
UniProt Annotation
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:14636993}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008285 negative regulation of cell proliferation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1915363
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VBV7
PhosphoSite PhosphoSite-Q8VBV7
TrEMBL
UniProt Splice Variant
Entrez Gene 108679
UniGene Mm.402128
RefSeq NP_598566
MGI ID
MGI Symbol Cops8
OMIM
CCDS CCDS15153
HPRD
IMGT
EMBL AF482000 AF502144 AK079111 AK079522 AK088323 AK090013 AK145899 AK162502 BC017690 BC021488 BC024421
GenPept AAH17690 AAH21488 AAH24421 AAL89689 AAP13731 BAC37543 BAC37670 BAC40281 BAC41045 BAE26735 BAE36948

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca