InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irx3

Summary

InnateDB Protein

IDBP-180023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irx3

Protein Name

Iroquois related homeobox 3 (Drosophila)

Synonyms

AI894186;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091002

InnateDB Gene

IDBG-180019 (Irx3)

Protein Structure

UniProt Annotation

Function

Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. {ECO:0000269PubMed:10830170, ECO:0000269PubMed:15201216}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed by neural progenitor cells in discrete domains of the ventral neural tube. Also expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is confined to the S3 segment of the proximal tubule, in the loop of Henle. {ECO:0000269PubMed:10830170, ECO:0000269PubMed:17875669}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001656	metanephros development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007498	mesoderm development
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0072047	proximal/distal pattern formation involved in nephron development
GO:0072086	specification of loop of Henle identity