InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccnt1

Summary

InnateDB Protein

IDBP-180496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccnt1

Protein Name

cyclin T1

Synonyms

2810478G24Rik; AI115585; CycT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000012104

InnateDB Gene

IDBG-180494 (Ccnt1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0017069	snRNA binding
GO:0019901	protein kinase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0051301	cell division