InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp5g3

Summary

InnateDB Protein

IDBP-180727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5g3

Protein Name

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018914

InnateDB Gene

IDBG-180725 (Atp5g3)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Disease Associations

Note=This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008289	lipid binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0008150	biological_process
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport

Cellular Component

GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)