Version 5.4
Homo sapiens Protein: SERPINA10
Summary
InnateDB Protein IDBP-18113.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA10
Protein Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261994
InnateDB Gene IDBG-18111 (SERPINA10)
Protein Structure
UniProt Annotation
Function Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. {ECO:0000269PubMed:11049983}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UK55
PhosphoSite PhosphoSite-Q9UK55
TrEMBL A0A024R6I6
UniProt Splice Variant
Entrez Gene 51156
UniGene Hs.118620
RefSeq NP_001094077
HUGO HGNC:15996
OMIM 605271
CCDS CCDS9923
HPRD 09245
IMGT
EMBL AF181467 AY358597 BC022261 BX248011 CH471061 EF621762
GenPept AAD53962 AAH22261 AAQ88960 ABR09269 CAD62339 EAW81565 EAW81566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca