InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF4B

Summary

InnateDB Protein

IDBP-1813.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF4B

Protein Name

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

Synonyms

SPGF13; TAF2C2; TAFII105;

Species

Homo sapiens

Ensembl Protein

ENSP00000269142

InnateDB Gene

IDBG-1811 (TAF4B)

Protein Structure

UniProt Annotation

Function

Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. {ECO:0000269PubMed:10828057, ECO:0000269PubMed:10849440, ECO:0000269PubMed:16088961}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.

Disease Associations

Tissue Specificity

Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells. {ECO:0000269PubMed:16088961, ECO:0000269PubMed:8858156}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046982	protein heterodimerization activity
GO:0051059	NF-kappaB binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process