Version 5.4
Mus musculus Protein: Bcas2
Summary
InnateDB Protein IDBP-181311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcas2
Protein Name breast carcinoma amplified sequence 2
Synonyms 6430539P16Rik; AI132645; C76366; C80030;
Species Mus musculus
Ensembl Protein ENSMUSP00000005830
InnateDB Gene IDBG-181309 (Bcas2)
Protein Structure
UniProt Annotation
Function Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008150 biological_process
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:1915433
InterPro IPR008409 Pre-mRNA-splicing factor SPF27
PFAM PF05700
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D287
PhosphoSite PhosphoSite-
TrEMBL Q05CL7
UniProt Splice Variant
Entrez Gene 68183
UniGene Mm.462483
RefSeq NP_080878
MGI ID
MGI Symbol Bcas2
OMIM
CCDS CCDS17691
HPRD
IMGT
EMBL AK005825 AK018786 AK020098 AK166967 AY043239 BC023382 BC037062 CH466608
GenPept AAH23382 AAH37062 AAK85306 BAB24258 BAB31409 BAB31992 BAE39150 EDL07598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca