InnateDB Protein
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IDBP-181611.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif3a
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Protein Name
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eukaryotic translation initiation factor 3, subunit A
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Synonyms
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A830012B05Rik; Csma; Eif3; Eif3s10; mKIAA0139;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025955
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InnateDB Gene
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IDBG-181609 (Eif3a)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03000}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9372446}. Nucleus {ECO:0000269PubMed:9372446}. Note=Centrosomin-A is found in the centrosome. Centrosomin-B is found in the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated |
Total |
40
[view]
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Protein-Protein |
40
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
75 [view]
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Molecular Function |
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Biological Process |
GO:0001731
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formation of translation preinitiation complex
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GO:0001732
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formation of translation initiation complex
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GO:0006446
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regulation of translational initiation
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Cellular Component |
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PDB ID |
MGI:95301
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InterPro |
IPR000717
Proteasome component (PCI) domain
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PFAM |
PF01399
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
P23116
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PhosphoSite |
PhosphoSite-P23116
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TrEMBL |
Q3UL99
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UniProt Splice Variant |
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Entrez Gene |
13669
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UniGene |
Mm.421887
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RefSeq |
NP_034253
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MGI ID |
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MGI Symbol |
Eif3a
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OMIM |
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CCDS |
CCDS38035
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HPRD |
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IMGT |
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EMBL |
AC163019
AK145629
AK149482
AK162784
AK167010
U14172
X17373
X84651
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GenPept |
AAA90910
BAE26550
BAE28908
BAE37058
BAE39186
CAA35246
CAA59144
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