InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP2B2

Summary

InnateDB Protein

IDBP-18193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2B2

Protein Name

ATPase, Ca++ transporting, plasma membrane 2

Synonyms

PMCA2; PMCA2a; PMCA2i;

Species

Homo sapiens

Ensembl Protein

ENSP00000353414

InnateDB Gene

IDBG-18189 (ATP2B2)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0019829	cation-transporting ATPase activity
GO:0030165	PDZ domain binding
GO:0030899	calcium-dependent ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006996	organelle organization
GO:0007595	lactation
GO:0007596	blood coagulation
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008361	regulation of cell size
GO:0021549	cerebellum development
GO:0021692	cerebellar Purkinje cell layer morphogenesis
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021707	cerebellar granule cell differentiation
GO:0030182	neuron differentiation
GO:0034220	ion transmembrane transport
GO:0040011	locomotion
GO:0042428	serotonin metabolic process
GO:0042472	inner ear morphogenesis
GO:0045299	otolith mineralization
GO:0046068	cGMP metabolic process
GO:0048167	regulation of synaptic plasticity
GO:0048839	inner ear development
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0051480	cytosolic calcium ion homeostasis
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060088	auditory receptor cell stereocilium organization
GO:0060113	inner ear receptor cell differentiation
GO:0070588	calcium ion transmembrane transport
GO:0090102	cochlea development

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
IPR008250 P-type ATPase, A domain
IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM