InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdha1

Summary

InnateDB Protein

IDBP-182648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdha1

Protein Name

pyruvate dehydrogenase E1 alpha 1

Synonyms

Pdha-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033662

InnateDB Gene

IDBG-182646 (Pdha1)

Protein Structure

UniProt Annotation

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269PubMed:11708858, ECO:0000269PubMed:20841503}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:19341700}.

Disease Associations

Tissue Specificity

In all tissues, but in very low amount in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004738	pyruvate dehydrogenase activity
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Biological Process

GO:0006006	glucose metabolic process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate
GO:0006096	glycolytic process
GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0043231	intracellular membrane-bounded organelle
GO:0045254	pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

MGI:97532

InterPro

IPR001017 Dehydrogenase, E1 component
IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35486

PhosphoSite