InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aqp9

Summary

InnateDB Protein

IDBP-182769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aqp9

Protein Name

aquaporin 9

Synonyms

1700020I22Rik; AI266899; AQP-9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074063

InnateDB Gene

IDBG-182767 (Aqp9)

Protein Structure

UniProt Annotation

Function

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005345	purine nucleobase transmembrane transporter activity
GO:0005350	pyrimidine nucleobase transmembrane transporter activity
GO:0015250	water channel activity
GO:0015254	glycerol channel activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0006863	purine nucleobase transport
GO:0010033	response to organic substance
GO:0015722	canalicular bile acid transport
GO:0015791	polyol transport
GO:0015793	glycerol transport
GO:0015837	amine transport
GO:0015855	pyrimidine nucleobase transport
GO:0046689	response to mercury ion
GO:0071320	cellular response to cAMP
GO:0072531	pyrimidine-containing compound transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0043231	intracellular membrane-bounded organelle