InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcf12

Summary

InnateDB Protein

IDBP-183197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf12

Protein Name

transcription factor 12

Synonyms

A130037E08Rik; ALF1; bHLHb20; HEB; HEBAlt; HTF-4; HTF4; ME1; REB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034755

InnateDB Gene

IDBG-183195 (Tcf12)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). {ECO:0000269PubMed:18214987}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010628	positive regulation of gene expression
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated