Version 5.4
Homo sapiens Protein: CLEC9A
Summary
InnateDB Protein IDBP-18379.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC9A
Protein Name C-type lectin domain family 9, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348074
InnateDB Gene IDBG-18377 (CLEC9A)
Protein Structure
UniProt Annotation
Function Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269PubMed:18497879, ECO:0000269PubMed:22483802}.
Subcellular Localization Membrane {ECO:0000269PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269PubMed:18408006}.
Disease Associations
Tissue Specificity In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes. {ECO:0000269PubMed:18408006, ECO:0000269PubMed:18497879}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXN8
PhosphoSite PhosphoSite-Q6UXN8
TrEMBL
UniProt Splice Variant
Entrez Gene 283420
UniGene Hs.606503
RefSeq NP_997228
HUGO HGNC:26705
OMIM 612252
CCDS CCDS8611
HPRD 16723
IMGT
EMBL AY358265 EU339276
GenPept AAQ88632 ABZ04557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca