Homo sapiens Protein: RPL21
Summary
InnateDB Protein IDBP-18391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL21
Protein Name ribosomal protein L21
Synonyms HYPT12; L21;
Species Homo sapiens
Ensembl Protein ENSP00000346027
InnateDB Gene IDBG-18389 (RPL21)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Note=Defects in RPL21 are a cause of generalized hypotrichosis simplex (HTS). A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.
Experimentally validated
Total 121 [view]
Protein-Protein 121 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
Protein Structure and Domains
PDB ID
InterPro IPR001147 Ribosomal protein L21e
IPR008991 Translation protein SH3-like domain
PFAM PF01157
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46778
PhosphoSite PhosphoSite-P46778
TrEMBL Q6IAX2
UniProt Splice Variant
Entrez Gene 619499
UniGene Hs.720640
RefSeq NP_000973
HUGO HGNC:10313
OMIM 603636
CCDS CCDS9320
HPRD 04700
IMGT
EMBL AB007176 AB061826 AK311795 AL159977 BC001603 BC007505 BC062981 BC070184 BC070323 BC070330 BC071902 BC104667 CH471075 CR457032 L38826 U14967 U25789 X89401
GenPept AAA80462 AAA85655 AAA93231 AAH01603 AAH07505 AAH62981 AAH70184 AAH70323 AAH70330 AAH71902 AAI04668 BAA25835 BAB79464 BAG34738 CAA61582 CAG33313 EAX08395 EAX08398