Version 5.4
Mus musculus Protein: Paip1
Summary
InnateDB Protein IDBP-184811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Paip1
Protein Name polyadenylate binding protein-interacting protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000026520
InnateDB Gene IDBG-184809 (Paip1)
Protein Structure
UniProt Annotation
Function Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0008494 translation activator activity
Biological Process
GO:0045727 positive regulation of translation
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2384993
InterPro IPR003890 MIF4G-like, type 3
IPR009818 Ataxin-2, C-terminal
IPR016024 Armadillo-type fold
PFAM PF02854
PF07145
PRINTS
PIRSF
SMART SM00543
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VE62
PhosphoSite PhosphoSite-Q8VE62
TrEMBL D3Z3J6
UniProt Splice Variant
Entrez Gene 218693
UniGene Mm.490243
RefSeq NP_663432
MGI ID
MGI Symbol Paip1
OMIM
CCDS CCDS26796
HPRD
IMGT
EMBL AC163689 AF128835 BC019726 BC051042
GenPept AAD28259 AAH19726 AAH51042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca