InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C7

Summary

InnateDB Protein

IDBP-18521.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

complement component 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322061

InnateDB Gene

IDBG-18519 (C7)

Protein Structure

UniProt Annotation

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

Subcellular Localization

Secreted.

Disease Associations

Complement component 7 deficiency (C7D) [MIM:610102]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. {ECO:0000269PubMed:8871666, ECO:0000269PubMed:9218625, ECO:0000269PubMed:9856499}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006883	cellular sodium ion homeostasis
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000884 Thrombospondin, type 1 repeat
IPR001862 Membrane attack complex component/perforin/complement C9
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR003884 Factor I / membrane attack complex
IPR020864 Membrane attack complex component/perforin (MACPF) domain

PFAM

PF00084
PF00090
PF00057
PF01823

PRINTS

PR00764
PR00261

PIRSF

SMART

SM00032
SM00209
SM00192
SM00057
SM00457

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt