InnateDB Protein
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IDBP-18540.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC6A1
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Protein Name
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solute carrier family 6 (neurotransmitter transporter, GABA), member 1
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Synonyms
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GABATHG; GABATR; GAT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000287766
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InnateDB Gene
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IDBG-18538 (SLC6A1)
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Protein Structure
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Function |
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005328
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neurotransmitter:sodium symporter activity
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GO:0005332
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gamma-aminobutyric acid:sodium symporter activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000175
Sodium:neurotransmitter symporter
IPR002980
Sodium:neurotransmitter symporter, GABA, GAT-1
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PFAM |
PF00209
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PRINTS |
PR00176
PR01195
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P30531
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PhosphoSite |
PhosphoSite-P30531
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TrEMBL |
C9J5P8
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UniProt Splice Variant |
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Entrez Gene |
6529
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UniGene |
Hs.443874
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RefSeq |
NP_003033
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HUGO |
HGNC:11042
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OMIM |
137165
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CCDS |
CCDS2603
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HPRD |
00664
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IMGT |
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EMBL |
AC024910
AK295702
BC033904
CH471055
X54673
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GenPept |
AAH33904
BAH12161
CAA38484
EAW64088
EAW64089
EAW64090
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