InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dct

Summary

InnateDB Protein

IDBP-186129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dct

Protein Name

dopachrome tautomerase

Synonyms

DT; slaty; slt; TRP-2; TRP2; Tyrp-2; Tyrp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022725

InnateDB Gene

IDBG-186127 (Dct)

Protein Structure

UniProt Annotation

Function

Involved in regulating eumelanin and phaeomelanin levels.

Subcellular Localization

Melanosome membrane; Single-pass type I membrane protein.

Disease Associations

Note=The slaty mutation in Tyrp2 leads to a decrease of DT activity and a consequent change in the pigmentation of the mice to a dark gray/brown eumelanin. The slaty-2j mutation has a similar phenotype, the slaty-lt (light) mutation has a more severe effect and is semidominant; its phenotype may be a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane.

Tissue Specificity

Melanocytes and retinal pigmented epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004167	dopachrome isomerase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0002052	positive regulation of neuroblast proliferation
GO:0006583	melanin biosynthetic process from tyrosine
GO:0008152	metabolic process
GO:0021847	ventricular zone neuroblast division
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0048468	cell development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

MGI:102563

InterPro

IPR002227 Tyrosinase copper-binding domain
IPR008922 Uncharacterised domain, di-copper centre

PFAM

PF00264

PRINTS

PR00092

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29812

PhosphoSite

PhosphoSite-P29812

TrEMBL

UniProt Splice Variant

Entrez Gene

13190

UniGene

RefSeq

NP_034154

MGI ID

MGI Symbol

Dct

OMIM

CCDS

CCDS27331

HPRD

IMGT

EMBL

BC067064 BC082330 CT025675 X63349 X85126

GenPept

AAH67064 AAH82330 CAA44951 CAA59440