InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajc3

Summary

InnateDB Protein

IDBP-186996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc3

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022734

InnateDB Gene

IDBG-186994 (Dnajc3)

Protein Structure

UniProt Annotation

Function

Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000269PubMed:12446838, ECO:0000269PubMed:20184891}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000269PubMed:12446838}.

Disease Associations

Tissue Specificity

Widely expressed, with high level in the liver. {ECO:0000269PubMed:8666242}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0051087	chaperone binding
GO:0051787	misfolded protein binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0031205	endoplasmic reticulum Sec complex
GO:0070062	extracellular vesicular exosome