InnateDB Protein
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IDBP-187106.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdca8
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Protein Name
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cell division cycle associated 8
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Synonyms
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4831429J16Rik; AU044747; BOR; Borealin; D4Ertd421e; DasraB; MESRGP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000081319
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InnateDB Gene
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IDBG-187104 (Cdca8)
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Protein Structure
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Function |
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1196274
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InterPro |
IPR018851
Borealin-like, N-terminal
IPR018867
Cell division protein borealin
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PFAM |
PF10444
PF10512
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BHX3
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PhosphoSite |
PhosphoSite-Q8BHX3
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TrEMBL |
E9Q2C7
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UniProt Splice Variant |
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Entrez Gene |
52276
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UniGene |
Mm.28038
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RefSeq |
NP_080836
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MGI ID |
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MGI Symbol |
Cdca8
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OMIM |
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CCDS |
CCDS18631
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HPRD |
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IMGT |
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EMBL |
AK003755
AK010905
AK020070
AK076065
AK076422
AK077717
AK077920
AK078404
AK082800
AL606933
AY550907
BC068181
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GenPept |
AAH68181
AAT34966
BAB22980
BAB27258
BAB31983
BAC36158
BAC36334
BAC36977
BAC37063
BAC37258
BAC38627
CAM16105
CAM16106
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