InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLRD1

Summary

InnateDB Protein

IDBP-18743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLRD1

Protein Name

killer cell lectin-like receptor subfamily D, member 1

Synonyms

CD94;

Species

Homo sapiens

Ensembl Protein

ENSP00000338130

InnateDB Gene

IDBG-18739 (KLRD1)

Protein Structure

UniProt Annotation

Function

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0045087	innate immune response
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001304 C-type lectin
IPR016187 C-type lectin fold

PFAM

PF00059

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13241

PhosphoSite

PhosphoSite-Q13241

TrEMBL

UniProt Splice Variant

Entrez Gene

3824

UniGene

Hs.668357

RefSeq

NP_002253

HUGO

HGNC:6378

OMIM

602894

CCDS

CCDS8621

HPRD

04204

IMGT

EMBL

AB009597 AB010084 AC022075 AJ000001 AJ000673 BC028009 U30610 Y14287 Y14288

GenPept

AAC50291 AAH28009 BAA24450 BAA24451 CAA03845 CAA04230 CAA74663