InnateDB Protein
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IDBP-187919.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atp6v0d1
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Protein Name
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ATPase, H+ transporting, lysosomal V0 subunit D1
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Synonyms
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Ac39; AI267038; Atp6d; P39; VATX; Vma6;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000013304
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InnateDB Gene
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IDBG-187917 (Atp6v0d1)
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Protein Structure
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Function |
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:12527205, ECO:0000269PubMed:12963731}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0008553
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hydrogen-exporting ATPase activity, phosphorylative mechanism
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GO:0015078
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hydrogen ion transmembrane transporter activity
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GO:0032403
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protein complex binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1201778
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InterPro |
IPR002843
ATPase, V0 complex, c/d subunit
IPR016727
ATPase, V0 complex, subunit d
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PFAM |
PF01992
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PRINTS |
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PIRSF |
PIRSF018497
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P51863
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PhosphoSite |
PhosphoSite-P51863
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11972
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UniGene |
Mm.462635
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RefSeq |
NP_038505
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MGI ID |
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MGI Symbol |
Atp6v0d1
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OMIM |
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CCDS |
CCDS22604
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HPRD |
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IMGT |
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EMBL |
AB088408
AK083372
AK171515
U13840
U21549
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GenPept |
AAA92288
AAC83085
BAC38889
BAC57954
BAE42500
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