InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp5k

Summary

InnateDB Protein

IDBP-188031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5k

Protein Name

ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e

Synonyms

2610008D24Rik; Atp5i; Lfm1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051222

InnateDB Gene

IDBG-188029 (Atp5k)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Mammary gland, liver, kidney, heart, spleen, brain and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739	mitochondrion
GO:0005753	mitochondrial proton-transporting ATP synthase complex