InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO4

Summary

InnateDB Protein

IDBP-18836.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO4

Protein Name

F-box protein 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000281623

InnateDB Gene

IDBG-18832 (FBXO4)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. {ECO:0000269PubMed:10531035, ECO:0000269PubMed:16275645, ECO:0000269PubMed:18598945, ECO:0000269PubMed:20159592, ECO:0000269PubMed:20181953}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000723	telomere maintenance
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination