Version 5.4
Mus musculus Protein: Adprhl2
Summary
InnateDB Protein IDBP-188432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adprhl2
Protein Name ADP-ribosylhydrolase like 2
Synonyms AI836109; Arh3;
Species Mus musculus
Ensembl Protein ENSMUSP00000099677
InnateDB Gene IDBG-188430 (Adprhl2)
Protein Structure
UniProt Annotation
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16278211}. Mitochondrion matrix {ECO:0000250}. Nucleus {ECO:0000269PubMed:16278211}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:16278211}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:2140364
InterPro IPR005502 ADP-ribosylation/Crystallin J1
PFAM PF03747
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CG72
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100206
UniGene Mm.11285
RefSeq NP_598644
MGI ID 2QTY
MGI Symbol Adprhl2
OMIM
CCDS CCDS18650
HPRD
IMGT
EMBL AJ427296 AK143583 AK147034 AK169070 AK171780 AL606976 BC010639 BC023177 BC045203
GenPept AAH10639 AAH23177 AAH45203 BAE25451 BAE27626 BAE40857 BAE42660 CAD20317 CAM45877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca