InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYBBP1A

Summary

InnateDB Protein

IDBP-18845.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYBBP1A

Protein Name

MYB binding protein (P160) 1a

Synonyms

P160; PAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000254718

InnateDB Gene

IDBG-18841 (MYBBP1A)

Protein Structure

UniProt Annotation

Function

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12429849}. Nucleus {ECO:0000269PubMed:12429849}. Nucleus, nucleolus {ECO:0000269PubMed:12429849}. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	98 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006261	DNA-dependent DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0042149	cellular response to glucose starvation
GO:0071158	positive regulation of cell cycle arrest
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0042564	NLS-dependent protein nuclear import complex
GO:0043231	intracellular membrane-bounded organelle