InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2c3

Summary

InnateDB Protein

IDBP-188541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2c3

Protein Name

eukaryotic translation initiation factor 2C, 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066633

InnateDB Gene

IDBG-188535 (Eif2c3)

Protein Structure

UniProt Annotation

Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. {ECO:0000255HAMAP- Rule:MF_03032, ECO:0000269PubMed:19174539}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03032}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035198	miRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006402	mRNA catabolic process
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0072091	regulation of stem cell proliferation

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0016020	membrane
GO:0016442	RISC complex
GO:0035068	micro-ribonucleoprotein complex

Protein Structure and Domains

PDB ID

MGI:2446634

InterPro

IPR003100 Argonaute/Dicer protein, PAZ domain
IPR003165 Stem cell self-renewal protein Piwi
IPR012337 Ribonuclease H-like domain
IPR014811 Domain of unknown function DUF1785

PFAM

PF02170
PF02171
PF08699

PRINTS

PIRSF

SMART

SM00949
SM00950

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CJF9