InnateDB Protein
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IDBP-188816.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cenpt
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Protein Name
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centromere protein T
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000038188
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InnateDB Gene
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IDBG-188814 (Cenpt)
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Protein Structure
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Function |
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome- associated complex that binds specifically to histone H3- containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443939
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InterPro |
IPR009072
Histone-fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3TJM4
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PhosphoSite |
PhosphoSite-Q3TJM4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
320394
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UniGene |
Mm.334775
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RefSeq |
NP_796124
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MGI ID |
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MGI Symbol |
Cenpt
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OMIM |
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CCDS |
CCDS22615
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HPRD |
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IMGT |
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EMBL |
AK089172
AK090340
AK143613
AK164039
AK167376
BC022690
BC121824
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GenPept |
AAH22690
AAI21825
BAC40776
BAC41176
BAE25464
BAE37599
BAE39471
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