InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tarbp2

Summary

InnateDB Protein

IDBP-188975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tarbp2

Protein Name

TAR (HIV) RNA binding protein 2

Synonyms

Prbp; TRBP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023813

InnateDB Gene

IDBG-188971 (Tarbp2)

Protein Structure

UniProt Annotation

Function

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR. Seems to act as a repressor of translation. {ECO:0000250, ECO:0000269PubMed:8649414}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03034, ECO:0000269PubMed:8649414}. Cytoplasm, perinuclear region {ECO:0000255HAMAP-Rule:MF_03034}. Nucleus {ECO:0000255HAMAP- Rule:MF_03034, ECO:0000269PubMed:8649414}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0035198	miRNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006417	regulation of translation
GO:0030422	production of siRNA involved in RNA interference
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031054	pre-miRNA processing
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070	positive regulation of viral genome replication
GO:0046782	regulation of viral transcription
GO:0050689	negative regulation of defense response to virus by host