InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd27

Summary

InnateDB Protein

IDBP-189752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd27

Protein Name

CD27 antigen

Synonyms

S152; Tnfrsf7; Tp55;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032486

InnateDB Gene

IDBG-189750 (Cd27)

Protein Structure

UniProt Annotation

Function

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

In thymus and spleen, but not in non-lymphoid tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045471	response to ethanol
GO:0045582	positive regulation of T cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0048305	immunoglobulin secretion
GO:0070233	negative regulation of T cell apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome