InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plekhg6

Summary

InnateDB Protein

IDBP-189901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekhg6

Protein Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037004

InnateDB Gene

IDBG-189899 (Plekhg6)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity