InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dazl

Summary

InnateDB Protein

IDBP-190405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dazl

Protein Name

deleted in azoospermia-like

Synonyms

Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010736

InnateDB Gene

IDBG-190403 (Dazl)

Protein Structure

UniProt Annotation

Function

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. {ECO:0000269PubMed:22021443, ECO:0000269PubMed:9288969}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9288969}.

Disease Associations

Tissue Specificity

Expressed predominantly in testis with lower levels in ovary. In testis, it is expressed in pachytene spermatocytes and at lower level in type-B spermatogonia, preleptotene and zygotene spermatocytes. In ovary, it is expressed in maturing follicles. In embryonic and prepuberal ovary, it is expressed in the oocyte and follicular cells. {ECO:0000269PubMed:9288969}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0008494	translation activator activity
GO:0042802	identical protein binding

Biological Process

GO:0001556	oocyte maturation
GO:0007147	female meiosis II
GO:0007275	multicellular organismal development
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0045836	positive regulation of meiosis
GO:0045948	positive regulation of translational initiation