InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dyrk3

Summary

InnateDB Protein

IDBP-190785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dyrk3

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016670

InnateDB Gene

IDBG-190783 (Dyrk3)

Protein Structure

UniProt Annotation

Function

Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling. {ECO:0000250UniProtKB:O43781, ECO:0000269PubMed:12356771}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:O43781}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030218	erythrocyte differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1330300

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt