InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OLIG2

Summary

InnateDB Protein

IDBP-1919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OLIG2

Protein Name

oligodendrocyte lineage transcription factor 2

Synonyms

BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17;

Species

Homo sapiens

Ensembl Protein

ENSP00000371794

InnateDB Gene

IDBG-1917 (OLIG2)

Protein Structure

UniProt Annotation

Function

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Tissue Specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. {ECO:0000269PubMed:11498220, ECO:0000269PubMed:11526205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.