Version 5.4
Mus musculus Protein: Kdm4b
Summary
InnateDB Protein IDBP-192053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kdm4b
Protein Name lysine (K)-specific demethylase 4B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025036
InnateDB Gene IDBG-192051 (Kdm4b)
Protein Structure
UniProt Annotation
Function Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00537}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005925 focal adhesion
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:2442355
InterPro IPR001965 Zinc finger, PHD-type
IPR002999 Tudor domain
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF00567
PF02373
PF08007
PF02375
PRINTS
PIRSF
SMART SM00249
SM00333
SM00558
SM00545
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VY5
PhosphoSite PhosphoSite-Q91VY5
TrEMBL Q8BLR3
UniProt Splice Variant
Entrez Gene 193796
UniGene Mm.45047
RefSeq NP_742144
MGI ID
MGI Symbol Kdm4b
OMIM
CCDS CCDS28904
HPRD
IMGT
EMBL AC026385 AK043678 AK129233 AK141879 BC005480 BC007145 CT009637
GenPept AAH05480 AAH07145 BAC31617 BAC98043 BAE24866

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca