InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx19a

Summary

InnateDB Protein

IDBP-192688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx19a

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a

Synonyms

DBP5; Ddx19; Eif4a-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047898

InnateDB Gene

IDBG-192686 (Ddx19a)

Protein Structure

UniProt Annotation

Function

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Nuclear pore complex cytoplasmic fibrils.

Disease Associations

Tissue Specificity

Found in testis, heart, brain, liver, skeletal muscle, and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding

Biological Process

GO:0008152	metabolic process
GO:0010043	response to zinc ion
GO:0015031	protein transport
GO:0043065	positive regulation of apoptotic process
GO:0051028	mRNA transport

Cellular Component

GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:99526

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61655