InnateDB Protein
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IDBP-19318.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GLCE
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Protein Name
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glucuronic acid epimerase
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Synonyms
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HSEPI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261858
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InnateDB Gene
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IDBG-19316 (GLCE)
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Protein Structure
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Function |
Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269PubMed:20118238}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016857
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racemase and epimerase activity, acting on carbohydrates and derivatives
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GO:0047464
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heparosan-N-sulfate-glucuronate 5-epimerase activity
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GO:0050379
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UDP-glucuronate 5'-epimerase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010598
D-glucuronyl C5-epimerase
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PFAM |
PF06662
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O94923
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PhosphoSite |
PhosphoSite-O94923
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TrEMBL |
H0YNP1
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UniProt Splice Variant |
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Entrez Gene |
26035
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UniGene |
Hs.183006
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RefSeq |
NP_056369
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HUGO |
HGNC:17855
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OMIM |
612134
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CCDS |
CCDS32277
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HPRD |
07020
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IMGT |
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EMBL |
AB020643
AC026512
AC026992
AY635582
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GenPept |
AAT48654
BAA74859
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