InnateDB Protein
|
IDBP-193770.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Adipor1
|
Protein Name
|
adiponectin receptor 1
|
Synonyms
|
2810031L11Rik; ACDCR1; CGI-45; Paqr1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000027727
|
InnateDB Gene
|
IDBG-193768 (Adipor1)
|
Protein Structure
|
|
Function |
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. {ECO:0000269PubMed:12802337}.
|
Subcellular Localization |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Expressed in heart, kidney, liver, lung, skeletal muscle and spleen. Weakly expressed in brain and testis. {ECO:0000269PubMed:12802337}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
8 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1919924
|
InterPro |
IPR004254
Hly-III-related
|
PFAM |
PF03006
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q91VH1
|
PhosphoSite |
PhosphoSite-Q91VH1
|
TrEMBL |
Q53YY4
|
UniProt Splice Variant |
|
Entrez Gene |
72674
|
UniGene |
Mm.472093
|
RefSeq |
NP_082596
|
MGI ID |
|
MGI Symbol |
Adipor1
|
OMIM |
|
CCDS |
CCDS15309
|
HPRD |
|
IMGT |
|
EMBL |
AK012847
AK143679
AK148140
AK151565
AK167896
AY424290
BC014875
CH466520
|
GenPept |
AAH14875
AAR08378
BAB28509
BAE25492
BAE28369
BAE30507
BAE39907
EDL39611
|
|
|