Version 5.4
Homo sapiens Protein: OTOA
Summary
InnateDB Protein IDBP-19390.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTOA
Protein Name otoancorin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373609
InnateDB Gene IDBG-19380 (OTOA)
Protein Structure
UniProt Annotation
Function May act as an adhesion molecule.
Subcellular Localization Apical cell membrane {ECO:0000305}; Lipid- anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes. {ECO:0000250}.
Disease Associations Deafness, autosomal recessive, 22 (DFNB22) [MIM:607039]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:11972037}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7RTW8
PhosphoSite PhosphoSite-Q7RTW8
TrEMBL B4DZ38
UniProt Splice Variant
Entrez Gene 146183
UniGene Hs.408336
RefSeq NP_733764
HUGO HGNC:16378
OMIM 607038
CCDS CCDS32403
HPRD 06126
IMGT
EMBL AC092719 AK057335 AK093062 AK125840 AK302733 BC129992 BC129993 BK000099
GenPept AAI29993 AAI29994 BAC04040 BAG54255 BAG63950 DAA00022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca