InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med11

Summary

InnateDB Protein

IDBP-194347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med11

Protein Name

mediator of RNA polymerase II transcription, subunit 11 homolog (S. cerevisiae)

Synonyms

1110030J09Rik; AI465144; AW545069;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019067

InnateDB Gene

IDBG-194345 (Med11)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008150	biological_process

Cellular Component

GO:0005654	nucleoplasm
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

MGI:1913422

InterPro

IPR019404 Mediator complex, subunit Med11

PFAM

PF10280

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D8C6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

66172

UniGene

RefSeq

NP_079673

MGI ID

MGI Symbol

Med11

OMIM

CCDS

CCDS24947

HPRD

IMGT

EMBL

AK003984 AK008153 AL596096 BC025057 CR936841

GenPept

AAH25057 BAB25497 BAE43156 CAI51988 CAM28187