InnateDB Protein
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IDBP-194776.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atf7ip
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Protein Name
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activating transcription factor 7 interacting protein
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Synonyms
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2610204M12Rik; AM; Mcaf1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000032335
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InnateDB Gene
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IDBG-194774 (Atf7ip)
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Protein Structure
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Function |
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). May have ATPase activity. {ECO:0000269PubMed:10777215, ECO:0000269PubMed:14536086}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10777215}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed at all stages studied. {ECO:0000269PubMed:10777215}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
57 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006200
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ATP catabolic process
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GO:0006306
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DNA methylation
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GO:0006351
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transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045898
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regulation of RNA polymerase II transcriptional preinitiation complex assembly
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Cellular Component |
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PDB ID |
MGI:1858965
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TT18
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PhosphoSite |
PhosphoSite-Q7TT18
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
54343
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UniGene |
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RefSeq |
NP_062299
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MGI ID |
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MGI Symbol |
Atf7ip
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OMIM |
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CCDS |
CCDS20651
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HPRD |
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IMGT |
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EMBL |
AJ132702
AK082697
AK134252
AK137199
AK157479
AK167542
BC022714
BC048827
BC052460
BC060246
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GenPept |
AAH22714
AAH48827
AAH52460
AAH60246
BAC38574
BAE22064
BAE23264
BAE34096
BAE39609
CAB77024
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