InnateDB Protein
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IDBP-195039.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Phlda3
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Protein Name
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pleckstrin homology-like domain, family A, member 3
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Synonyms
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Tih1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040614
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InnateDB Gene
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IDBG-195037 (Phlda3)
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Protein Structure
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Function |
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12374806}. Membrane {ECO:0000269PubMed:12374806}; Peripheral membrane protein {ECO:0000269PubMed:12374806}.
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Disease Associations |
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Tissue Specificity |
Widely expressed in fetal tissues, with the exception of liver. Strongly expressed in adult skeletal muscle and lung. Widely expressed at lower levels in other adult tissues, with weakest expression in liver and spleen. {ECO:0000269PubMed:10594239}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
89 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005546
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phosphatidylinositol-4,5-bisphosphate binding
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GO:0005547
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phosphatidylinositol-3,4,5-trisphosphate binding
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GO:0010314
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phosphatidylinositol-5-phosphate binding
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GO:0032266
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phosphatidylinositol-3-phosphate binding
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GO:0043325
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phosphatidylinositol-3,4-bisphosphate binding
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GO:0080025
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phosphatidylinositol-3,5-bisphosphate binding
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Biological Process |
GO:0042771
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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:0043065
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positive regulation of apoptotic process
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GO:0051898
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negative regulation of protein kinase B signaling
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Cellular Component |
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PDB ID |
MGI:1351485
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WV95
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PhosphoSite |
PhosphoSite-Q9WV95
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27280
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UniGene |
Mm.34346
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RefSeq |
NP_038778
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MGI ID |
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MGI Symbol |
Phlda3
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OMIM |
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CCDS |
CCDS35722
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HPRD |
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IMGT |
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EMBL |
AF151099
AK003767
BC023408
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GenPept |
AAD42080
AAH23408
BAB22985
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