InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bdh2

Summary

InnateDB Protein

IDBP-195318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdh2

Protein Name

3-hydroxybutyrate dehydrogenase, type 2

Synonyms

1810026B04Rik; Dhrs6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029817

InnateDB Gene

IDBG-195316 (Bdh2)

Protein Structure

UniProt Annotation

Function

Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase. {ECO:0000269PubMed:20550936}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:20550936}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003858	3-hydroxybutyrate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0019290	siderophore biosynthetic process
GO:0030855	epithelial cell differentiation
GO:0042168	heme metabolic process
GO:0055072	iron ion homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1917022

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8JZV9

PhosphoSite

PhosphoSite-Q8JZV9

TrEMBL

UniProt Splice Variant

Entrez Gene

69772

UniGene

RefSeq

MGI ID

MGI Symbol

Bdh2

OMIM

CCDS

CCDS17853

HPRD

IMGT

EMBL

BC036998

GenPept

AAH36998