InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alas1

Summary

InnateDB Protein

IDBP-195830.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alas1

Protein Name

aminolevulinic acid synthase 1

Synonyms

ALAS; Alas-1; Alas-h; ALAS-N;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073725

InnateDB Gene

IDBG-195828 (Alas1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003870	5-aminolevulinate synthase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0009058	biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:87989

InterPro

IPR004839 Aminotransferase, class I/classII
IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
IPR015118 5-aminolevulinate synthase presequence
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00155
PF09029

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VC19

PhosphoSite